Menopause Hack: What Is Spermidine?

Spermi-WHAT?! is the response I usually get when I mention spermidine to someone. Lol. I get it. It sounds like sperm, and actually…this is no coincidence; it was originally discovered in sperm and dubbed the key to sexual longevity in ancient Japanese scriptures. Your body naturally produces it when you are young, but this declines with age and as a result, so does your ability to induce autophagy. Auto-what?! That’s the next question. You can listen to this podcast to get the full explanation on autophagy, or you can just understand that autophagy is the body’s natural cellular clean-up and recycling process to keep the body functioning at optimal levels. 

So autophagy is something that comes with healthy levels of spermidine…that’s why we can feel so good when we activate autophagy.

So, to recap, spermidine is able to target the root causes of aging, such as inhibiting dysfunctional stem cells and mitochondria and activating autophagy. It is easily the most effective anti-aging tool money can buy. 

So, how can spermidine help with menopause? So far what the research shows and what I have been hearing from the Hack My Age community who have been testing out my favorite spermidine supplement Primeadine® are:

  • Enhanced hair growth (including lashes and brows) and gray hair reversal
  • Deeper, sounder sleep, as seen by clients’ wearable sleep-tracking devices
  • Improved hormonal balance
  • Clearer, more vital skin
  • Stronger, healthier nails
  • Youthful energy levels
  • Better gut health
  • Less brain fog and better memory
  • Improved mood

These are some of the most complained about symptoms of menopause, so you can see why I am so excited about it when I hear yet another great testimonial from our Hack My Age family. And by the way, spermidine is also a fasting mimetic, which totally flies by book, because I am not a huge fan of fasting for women, unless done appropriately in certain conditions. Now, I can get my fasting benefits without having to starve myself nor suffer the negative consequences.

Guess what? Spermidine can also help you get your youthful vitality and sex drive back… The fact it’s called spermidine says it all. 

And while it’s working on our libido, we should also mention how this is tied into our heart health. Well, spermidine helps increase nitric oxide production, AKA blood flow, to all the right places! This means your heart (and other vital organs…) will be able to work faster and harder for you too. Better yet, since spermidine is shown to increase testosterone in men, you (or your partner) will actually have the energy and stamina to enjoy it. What’s not to love?

Spermidine is my ticket to high-performance, healthy cells, triggering rejuvenation throughout my body. With consistent use, I think you’ll find yourself with the radiant glow, energy, and vitality of your youth, enabling you to perform better in every aspect of your life 😉

When it comes to brands, the only spermidine I trust  is Primeadine®, because it is wholly food-derived – the only kind of spermidine tested for safety and effectiveness in humans. 

Unlike synthetic versions, Primeadine® Original reactivates your natural ability to produce spermidine. This is all thanks to a special formula that includes a unique prebiotic fiber to help your spermidine-producing gut bacteria thrive and multiply. Believe me, other companies do not take this extra step. It’s of course, more expensive to do so.

Plant-derived spermidine also contains the naturally co-occurring polyamines, putrescine (spermidine’s precursor) and spermine (spermidine’s successor), which recycle into each other to make more spermidine. It’s more bang for your buck in each bottle.

Primeadine® GF – Oxford Healthspan’s gluten-free formula – contains 3 potent autophagy inducers and anti-inflammatories, all sourced from the longevity Blue Zone of Okinawa, Japan. These are a unique spermidine-rich substrain of chlorella, turmeric, and nobiletin (from “Shikuwasa” citrus lime peel), and thanks to the chlorella, provides naturally occurring B12, iron, vitamin D, biotin, and lutein. 

In addition, Primeadine® is sourced in Japan, home to some of the world’s healthiest, longest-lived people and superior food quality and safety standards. This makes it the cleanest, purest spermidine supplement out there, free from hidden impurities like heavy metals, pesticides, omega-6 fatty acids, synthetic chemicals, fillers, and flow agents. 

One big reason reason I only take Primeadine® spermidine is because in 2020 I met Leslie Kenny, the founder of Oxford Healthspan (the creator of Primeadine®). I was very impressed by her passion to help other women with the benefits of spermidine, but I completely connected with her as a person. And over the years I learned more and more about her integrity, her strong stance to only deliver the best ingredients and to never EVER cut corners just to make a profit, as unfortunately so many other supplement companies do. You should really listen to this podcast we did together on how competitor spermidine supplement companies “soak” or “cut” their products in synthetic spermidine (which, by the way, does not have rigorous testing for safety) and cut corners to increase the amount of “so called” spermidine to falsely impress customers who have “the more, the better” mentality and of course to make more profit.

So Primeadine® is not only for me the gold standard when it comes to supplement manufacturing, I have now seen Leslie prove the efficacy, quality and standard of her product by the 100s of testimonials I get regularly from the Hack My Age community. I even have a highlight on my Instagram page right here all about these stories.

And this brings me to my last reason why I am such a fan of Primeadine® spermidine. Of course, I have had my own successes with Primeadine®, mostly improved sleep scores on my sleep monitoring devices, but more importantly hearing from so many women rave about the benefits after I recommended they try. So with each testimonial I hear, I am more and more confident that Primeadine® works.

I recommend you to test Primeadine® out for yourself using this link and/or the code ZORA for 15% off right here.

And if you do try it out, you MUST absolutely share your own experience with me. I love collecting new stories!



Ramos-Molina B, Queipo-Ortuño MI, Lambertos A, Tinahones FJ, Peñafiel R. Dietary and Gut Microbiota Polyamines in Obesity- and Age-Related Diseases. Front Nutr. 2019 Mar 14;6:24. doi: 10.3389/fnut.2019.00024. PMID: 30923709; PMCID: PMC6426781.


Madeo F, Eisenberg T, Pietrocola F, Kroemer G. Spermidine in health and disease. Science. 2018 Jan 26;359(6374):eaan2788. doi: 10.1126/science.aan2788. PMID: 29371440.



Join the Biohacking Menopause membership program or select any of the Hack My Age menopause programs to get more clarity and guidance for your personal situation. Or check out the Freebies page for plenty of free resources.

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